I have not see any info updated in posts or in the main link https://boinc.bakerlab.org/rosetta/rah_medical_relevance.php about what we are doing.. is there any up date??

Aalelan

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Hi Aalelan,

Perhaps the best place to look would be:
http://bakerlab.org

There you can find a twitter feed, and projects/papers that have been published by the Baker Lab.
Most (if not all) of these projects have used Rosetta@home at some stage, especially the more recent projects!

Rosetta@home is being extensively used to test designed proteins.

Lets say you come up with an interesting shape (protein fold to perform a specific function), you can use a number of methods to come up with sequence that you hope will adopt this shape. One way to test if this is the correct sequence is to run a folding simulation. More importantly you'd want to know if it can adopt any other conformation and have a similar score or better score. This is where your computer comes in!

Check out the following twitter post by Lucas:
https://twitter.com/lucas_nivon/status/396345660183564288/photo/1

Each one of those dots is a rosetta@home job!! The green dots come from the wiggled designed structure. The red jobs are the output of a folding simulation. What we want to see is a funnel towards the green dots.

Hi Aalelan

I've recently joined the Baker Lab and Institute for Protein Design as a scientific/technical writer.

I just started a new thread in the message boards called: Rosetta@home Research Updates

I will be regularly posting updates to that thread about the research that has greatly benefited from Rosetta@home users! I will also be including links to the relevant publications. Hopefully this will be helpful in keeping the R@h community updated on all of the exciting protein design work.

In addition to the Baker Laboratory web page, please explore the web page for the Institute for Protein Design (http://depts.washington.edu/ipd/). There is a News section there you might enjoy browsing.